منابع مشابه
Pathogenesis of Lassa Fever
Lassa virus, an Old World arenavirus (family Arenaviridae), is the etiological agent of Lassa fever, a severe human disease that is reported in more than 100,000 patients annually in the endemic regions of West Africa with mortality rates for hospitalized patients varying between 5-10%. Currently, there are no approved vaccines against Lassa fever for use in humans. Here, we review the publishe...
متن کاملDetection of Lassa Virus, Mali
To determine whether Lassa virus was circulating in southern Mali, we tested samples from small mammals from 3 villages, including Soromba, where in 2009 a British citizen probably contracted a lethal Lassa virus infection. We report the isolation and genetic characterization of Lassa virus from an area previously unknown for Lassa fever.
متن کاملLassa Fever, Nigeria, 2005–2008
To the Editor: Lassa fever affects ≈100,000 persons per year in West Af-rica (1). The disease is caused by Las-sa virus, an arenavirus, and is associated with bleeding and organ failure. The case-fatality rate in hospitalized patients is 10%–20%. The reservoir of the virus is multimammate mice (Mastomys natalensis). Investigations in the 1970s and 1980s pointed to the existence of 3 disease-end...
متن کاملReplicon system for Lassa virus.
Lassa virus is endemic to West Africa and causes hemorrhagic fever in humans. To facilitate the functional analysis of this virus, a replicon system was developed based on Lassa virus strain AV. Genomic and antigenomic minigenomes (MG) were constructed consisting of the intergenic region of S RNA and a reporter gene (Renilla luciferase) in antisense orientation, flanked by the 5' and 3' untrans...
متن کاملCharacterization of Lassa virus cell entry and neutralization with Lassa pseudoparticles
192 Text: 5,646, Figures: 5, Tables: 1 AC CE PT ED Copyright © 2009, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved. J. Virol. doi:10.1128/JVI.01711-08 JVI Accepts, published online ahead of print on 19 January 2009
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ژورنال
عنوان ژورنال: Journal of Endocrinology, Metabolism and Diabetes of South Africa
سال: 2009
ISSN: 1608-9677,2220-1009
DOI: 10.1080/22201009.2009.10872184